BioWorld

Medshine Discovery presents new PTPN11 inhibitors

Medshine Discovery Inc. has patented selenium-containing compounds acting as tyrosine-protein phosphatase non-receptor type 11 (PTPN11) inhibitors reported to be useful for the treatment of cancer.
BioWorld

Hinova Pharmaceuticals identifies new PTPN11-targeting PROTACs

Hinova Pharmaceuticals Inc. has presented proteolysis targeting chimera (PROTAC) compounds comprising E3 ubiquitin ligase-binding moiety covalently linked to tyrosine-protein phosphatase nonreceptor ...
ascopubs.org

Impact of variant allele frequency of mutant PTPN11 in AML: Single institution experience of 122 patients.

Feasibility of HSCT vs consolidation therapy for AML patients aged 60-75 in CR1: A randomized phase III, multicentre EBMT study.
Science Daily

Researchers create 'leukemia in a dish' to better study it

Scientists engineered stem cells to better understand the mechanisms behind a form of leukemia caused by changes in a key gene, according to a new study. Scientists engineered stem cells to better ...
Nature

SOS1 and PTPN11 mutations in five cases of Noonan syndrome with multiple giant cell lesions

Pigmented villonodular synovitis (PVS) is a benign proliferative disorder of the synovial tissue, which may affect the synovial-lined large joints (more commonly the knee and ankle) or tendon sheaths ...